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KMID : 0895820130230030015
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Journal of Oriental Rehabilitation Medicine
2013 Volume.23 No. 3 p.15 ~ p.26
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Antibacterial Effect of Huanggeumjakyak-tang against Methicillin-resistant Staphylococcus aureus
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Kim Esther
Choi Chong-Hwan
Kim Il-Hyun
Lee Ha-Il
Song Yung-Sun
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Abstract
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Objectives : The aim of this study was to investigate antimicrobial activity of Huanggeumjakyak-tang water extract against MRSA.
Methods : The antibacterial activities of Huanggeumjakyak-tang were evaluated against 3 strains of Methicillin-resistant Staphylococcus aureus (MRSA) and 1 standard Methicillin- susceptible S. aureus (MSSA) strain by using the disc diffusion method, minimal inhibitory concentrations (MICs) assay, colorimetric assay using MTT test, checkerboard dilution test and time-kill assay was performed under dark.
Results : The MIC (minimum inhibitory concentration) of Huanggeumjakyak-tang water extract against S. aureus strains ranged from 1,000 to 2,000μg/ml. So we confirmed that it has a strong antibacterial effect. Also the combinations of Huanggeumjakyak-tang water extract and conventional antibiotics exhibited improved inhibition of MRSA with synergy effect.
Conclusions : The results obtained in this study suggest that Huanggeumjakyak-tang water extract showed antibacterial effect against MRSA, and it also showed reducing effect on the side-effect problems that are the major weak points of traditional antibiotics. (J Korean Med Rehab 2013;23(
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KEYWORD
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Huanggeumjakyak-tang, MRSA, Antibacterial effect
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